區別是：

be wrong with意思是引起問題（或麻煩）；有毛病，不正常。

be wrong about意思是出錯，弄錯，有錯誤。

例句：

be wrong with

1、What seems to be wrong with you?

你像是怎麼了？

2、Something must be wrong with my leg.

我的腿肯定有毛病了。

3、Something must be wrong with the work.

一定是機件有毛病了。

4、Something must be wrong with the computer because as there"s nothing on the screen.

電腦肯定是出問題了，因為螢幕上什麼也沒有。

be wrong about

1、He could be wrong about her. The feeling nagged at him.

他可能冤枉她了，這種感覺讓他備受折磨。

2、I might be wrong about that.

在那件事上我可能錯了。

3、You would be wrong about that.

如果您這樣想就錯了。

4、I might be wrong about that but I have a feeling I used that as an example as one of the ones that was valid in virtue of their form.

我可能錯了，但是我覺得我用過一個例子，當做透過形式有效的例子。