2021英雄聯盟全球總決賽主題曲是《不可阻擋》，由Alex Seaver作詞， PVRIS演唱；於2021年9月29日發行。

歌詞：

This ain't where the legends come from

You're not what a hero looks like

Pretty little flower won't you sit back down and go play nice

Keep talking keep laughing

One day you'll wish you hadn't

All the people want fire fire

Maybe it's time they meet their dragon

If you're gonna hold me down

And you're not gonna let me in

Into your castle walls

None of you can keep them

Cause if I gotta

Bu bu burn it all down

Then we'll burn it all down

My oh my look at who end up bigger this time

And if I gotta

Bu bu break it all down

Then let's break it all down

Bye bye bye

Playing with fire

And we burn it all down

This is where the bruises come from

This is when the game gets ugly

These blood sweat tears keep running

Licking my plate 'cause I'm so hungry

Keep talking keep laughing

One day you'll see what happens

All the people want fire fire

It's about time they meet their dragon

If you're gonna hold me down

And you're not gonna let me in

Into your castle walls

None of you can keep them

Cause if I got