區別就是兩者意思是不一樣具體的不同如下

make a difference to中文意思是對……產生影響;

例句

And that the characteristics adult children look for when they begin the search are not necessarily the things that make a difference to the people who are going to move in.

成年子女在開始尋找養老機構時所關注的那些特色，對於將要入住的人來說未必事關重要。

make a difference in中文意思是對…有關系,影響

make a difference to 對什麼有影響

make a difference in 使……不同

make a difference to do sth

make a difference in sth

就是這個區別

以後看到……+in 一般後面都是加sth

看到……+to 一般後面都是加do sth