18 January 2021

Biomolecular condensates and cancer(Cancer Cell, IF:26.602)

Boija Ann,Klein Isaac A,Young Richard A,Biomolecular condensates and cancer.[J] .Cancer Cell, 2020, undefined: undefined.

Malignant transformation is characterized by dysregulation of diverse cellular processes that have been the subject of detailed genetic, biochemical, and structural studies, but only recently has evidence emerged that many of these processes occur in the context of biomolecular condensates. Condensates are membrane-less bodies, often formed by liquid-liquid phase separation, that compartmentalize protein and RNA molecules with related functions. New insights from condensate studies portend a profound transformation in our understanding of cellular dysregulation in cancer. Here we summarize key features of biomolecular condensates, note where they have been implicated-or will likely be implicated-in oncogenesis, describe evidence that the pharmacodynamics of cancer therapeutics can be greatly influenced by condensates, and discuss some of the questions that must be addressed to further advance our understanding and treatment of cancer.

惡性轉化的特徵是多種細胞過程的失調，這是詳細的遺傳、生化和結構研究的主題，但直到最近才有證據表明，許多這些過程發生在生物分子凝聚物的背景下。凝聚物是無膜體，通常由液-液相分離形成，將具有相關功能的蛋白質和RNA分子分隔開來。凝聚物研究的新見解預示著我們對癌症細胞失調的理解將發生深刻轉變。這裡我們總結關鍵特性的生物分子凝聚，請注意，他們一直涉及或可能會涉及腫瘤形成，描述證據表明癌症療法的藥效學能夠極大地受到凝聚物的影響，並討論必須解決的一些問題，進一步推進我們理解和治療癌症。